VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptors--the P-selectin ligand, PSGL-1, and heparan sulfate glycosaminoglycan--with no effect on virus ...

Genetic Diversity of Enterovirus A71, India

We have identified circulation of 3 genogroups of enterovirus (EV) A71 in India. A new genogroup (proposed designation G) was discovered during this study. We isolated genogroups D and G in wide geographic areas but detected subgenogroup C1 only in 1 focus in western India. A systematic nationwide search for EV-A71 is warranted.

Adhesion of Human Malignant Melanoma Heparan Sulfate-Like Proteoglycans Mediate

Enterovirus EV-A71 Vaccine Licensure: What’s next?

Submit Manuscript | http://medcraveonline.com neurological complications and cardiopulmonary diseases in young children [1-5]. In the past two decades, coxsackievirus A16 (CV-A16) and enterovirus 71 (EV-A71) have been the predominant etiologic agents of herpangina (HA) and hand, foot and mouth disease (HFMD) epidemics [5-7]. Several other enterovirus serotypes frequently co-circulate with EV-A7...

Enterovirus A71 Subgenotype B5, France, 2013

To the Editor: We report the detection of human enterovirus A71 (EV-A71) subgenotype B5 in France, 6 years after it was first detected in Europe. EV-A71 belongs to the Enterovirus A species (genus Enterovirus, family Picornaviridae) and is a major cause of hand, foot and mouth disease (HFMD), sometimes associated with severe neurologic complications (1). EV-A71 strains are classified in 6 genot...